Bisindolylmaleimide I . hydrochloride [GF-109203X; Goe 6850] [176504-36-2]

AdipoGen Life Sciences

Bisindolylmaleimide I . hydrochloride [GF-109203X; Goe 6850]

10

176504-36-2

Research Use Only

>98%

C25H24N4O2 . HCl

412.5 . 36.5

Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM) [1]. Competitive inhibitor for the ATP-binding site of PKC [1]. Anti-inflammatory [2]. Binds to P-glycoprotein [3]. Telomerase activity inhibitor [4]. Potent glycogen synthase kinase-3 (GSK-3) inhibitor [5]. Necrosis inhibitor [6]. Blocks hERG potassium channels [7-9]. Promotes osteoblastogenesis in human mesenchymal stem cells [10]. - Chemical. CAS: 176504-36-2. Formula: C25H24N4O2 . HCl. MW: 412.5 . 36.5. Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.

Cl.CN(C)CCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2

-20°C,2°C to 8°C

51202000