c-Met antibody [3i20(25H2)]

GeneTex

c-Met antibody [3i20(25H2)] - Orthogonal Validated

9

Recognizes endogenous levels of human Met at ~145kD and at 170kD for pro-Met.

WB: 1:1000. IP: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

3i20(25H2)

Unconjugated

MET

MET proto-oncogene, receptor tyrosine kinase

AUTS9; c-Met; DFNB97; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; HGFR; proto-oncogene c-Met; RCCP2; scatter factor receptor; SF receptor; tyrosine-protein kinase Met

Mouse

IgG1

Hepatocyte growth factor receptor

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Human, Monkey, Mouse, Primate, Rat

-20°C or -80°C,2°C to 8°C

12352203