c-Met (phospho Tyr1234) antibody [HL2907]

GeneTex

c-Met (phospho Tyr1234) antibody [HL2907]

7

This antibody detects c-Met when singly phosphorylated at Tyr1234 or dually phosphorylated at Tyr1234 and Tyr1235, but it does not recognize c-Met when singly phosphorylated at Tyr1235.

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Monoclonal

HL2907

1 mg/ml

Unconjugated

MET

MET proto-oncogene, receptor tyrosine kinase

AUTS9; c-Met; DFNB97; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; HGFR; proto-oncogene c-Met; RCCP2; scatter factor receptor; SF receptor; tyrosine-protein kinase Met

Rabbit

IgG

Hepatocyte growth factor receptor

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Human

-20°C or -80°C,2°C to 8°C

12352203