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ProductsBack/C9orf72 antibody [GT1553-RB]
C9orf72 antibody [GT1553-RB] detects C9orf72 protein at cytoplasm by immunofluorescent analysis. Sample: DIV10 rat E18 primary hippocampal neuron cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: C9orf72 stained by C9orf72 antibody [GT1553-RB] (GTX635398) diluted at 1:250. Red: Tau, a cytoskeleton marker, stained by Tau antibody [GT287] (GTX634809) diluted at 1:500. Blue: Fluoroshield with DAPI (GTX30920).
C9orf72 antibody [GT1553-RB] detects C9orf72 protein at cytoplasm by immunofluorescent analysis. Sample: DIV10 rat E18 primary hippocampal neuron cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: C9orf72 stained by C9orf72 antibody [GT1553-RB] (GTX635398) diluted at 1:250. Red: Tau, a cytoskeleton marker, stained by Tau antibody [GT287] (GTX634809) diluted at 1:500. Blue: Fluoroshield with DAPI (GTX30920).
C9orf72 antibody [GT1553-RB] detects C9orf72 protein at cytoplasm by immunofluorescent analysis. Sample: DIV10 rat E18 primary hippocampal neuron cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: C9orf72 stained by C9orf72 antibody [GT1553-RB] (GTX635398) diluted at 1:250. Red: Tau, a cytoskeleton marker, stained by Tau antibody [GT287] (GTX634809) diluted at 1:500. Blue: Fluoroshield with DAPI (GTX30920).

C9orf72 antibody [GT1553-RB]

GTX635398
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetC9orf72
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Overview

  • Supplier
    GeneTex
  • Product Name
    C9orf72 antibody [GT1553-RB]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GT1553-RB
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID203228
  • Target name
    C9orf72
  • Target description
    C9orf72-SMCR8 complex subunit
  • Target synonyms
    ALSFTD, DENND9, DENNL72, FTDALS, FTDALS1, guanine nucleotide exchange factor C9orf72, guanine nucleotide exchange C9orf72, protein C9orf72
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ96LT7
  • Protein Name
    Guanine nucleotide exchange factor C9orf72
  • Scientific Description
    The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5 exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    41116161

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