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ProductsBack/C9orf72 antibody [GT779]

C9orf72 antibody [GT779]

GTX632041
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetC9orf72
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Overview

  • Supplier
    GeneTex
  • Product Name
    C9orf72 antibody [GT779]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GT779
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID203228
  • Target name
    C9orf72
  • Target description
    C9orf72-SMCR8 complex subunit
  • Target synonyms
    ALSFTD, DENND9, DENNL72, FTDALS, FTDALS1, guanine nucleotide exchange factor C9orf72, guanine nucleotide exchange C9orf72, protein C9orf72
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ96LT7
  • Protein Name
    Guanine nucleotide exchange factor C9orf72
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chen ZS, Ou M, Taylor S, et al. Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD. Nat Commun. 2023,14(1):8420. doi: 10.1038/s41467-023-44215-w
    Read this paper
  • Seidel M, Rajkumar S, Steffke C, et al. Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models. Curr Res Neurobiol. 2023,5:100105. doi: 10.1016/j.crneur.2023.100105
    Read this paper
  • Ghaffari LT, Trotti D, Haeusler AR. Differential response of C9orf72 transcripts following neuronal depolarization. iScience. 2023,26(6):106959. doi: 10.1016/j.isci.2023.106959
    Read this paper
  • Jülg J, Edbauer D, Behrends C. C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains. EMBO Rep. 2023,24(8):e55895. doi: 10.15252/embr.202255895
    Read this paper
  • Pang W, Hu F. C9ORF72 suppresses JAK-STAT mediated inflammation. iScience. 2023,26(5):106579. doi: 10.1016/j.isci.2023.106579
    Read this paper
  • Bauer CS, Cohen RN, Sironi F, et al. An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD. Acta Neuropathol. 2022,144(3):437-464. doi: 10.1007/s00401-022-02470-z
    Read this paper
  • Liu Y, Xing H, Ernst AF, et al. Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice. Mol Cell Neurosci. 2022,121:103756. doi: 10.1016/j.mcn.2022.103756
    Read this paper
  • Liu Y, Dodart JC, Tran H, et al. Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models. Nat Commun. 2021,12(1):847. doi: 10.1038/s41467-021-21112-8
    Read this paper
  • Laflamme C, McKeever PM, Kumar R, et al. Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. Elife. 2019,8. doi: 10.7554/eLife.48363
    Read this paper

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Figure 1. Western blot analysis of C9ORF72 using anti-C9ORF72 antibody (A00419-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human placenta tissue lysates, Lane 2: human U2OS whole cell lysates, Lane 3: human PC-3 whole cell lysates, Lane 4: human K562 whole cell lysates, Lane 5: human Hela whole cell lysates, Lane 6: human A431 whole cell lysates, Lane 7: human A549 whole cell lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-C9ORF72 antigen affinity purified polyclonal antibody (Catalog # A00419-1) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for C9ORF72 at approximately 65KD. The expected band size for C9ORF72 is at 65KD.
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