C9orf72 antibody [GT779]
GTX632041
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetC9orf72
Overview
- SupplierGeneTex
- Product NameC9orf72 antibody [GT779]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDGT779
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID203228
- Target nameC9orf72
- Target descriptionC9orf72-SMCR8 complex subunit
- Target synonymsALSFTD, DENND9, DENNL72, FTDALS, FTDALS1, guanine nucleotide exchange factor C9orf72, guanine nucleotide exchange C9orf72, protein C9orf72
- HostMouse
- IsotypeIgG1
- Protein IDQ96LT7
- Protein NameGuanine nucleotide exchange factor C9orf72
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Chen ZS, Ou M, Taylor S, et al. Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD. Nat Commun. 2023,14(1):8420. doi: 10.1038/s41467-023-44215-wRead this paper
- Seidel M, Rajkumar S, Steffke C, et al. Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models. Curr Res Neurobiol. 2023,5:100105. doi: 10.1016/j.crneur.2023.100105Read this paper
- Ghaffari LT, Trotti D, Haeusler AR. Differential response of C9orf72 transcripts following neuronal depolarization. iScience. 2023,26(6):106959. doi: 10.1016/j.isci.2023.106959Read this paper
- Jülg J, Edbauer D, Behrends C. C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains. EMBO Rep. 2023,24(8):e55895. doi: 10.15252/embr.202255895Read this paper
- Pang W, Hu F. C9ORF72 suppresses JAK-STAT mediated inflammation. iScience. 2023,26(5):106579. doi: 10.1016/j.isci.2023.106579Read this paper
- Bauer CS, Cohen RN, Sironi F, et al. An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD. Acta Neuropathol. 2022,144(3):437-464. doi: 10.1007/s00401-022-02470-zRead this paper
- Liu Y, Xing H, Ernst AF, et al. Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice. Mol Cell Neurosci. 2022,121:103756. doi: 10.1016/j.mcn.2022.103756Read this paper
- Liu Y, Dodart JC, Tran H, et al. Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models. Nat Commun. 2021,12(1):847. doi: 10.1038/s41467-021-21112-8Read this paper
- Laflamme C, McKeever PM, Kumar R, et al. Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. Elife. 2019,8. doi: 10.7554/eLife.48363Read this paper
Datasheet
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