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ProductsBack/C9orf72 antibody [GT779]

C9orf72 antibody [GT779]

GTX632041
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetC9orf72
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Overview

  • Supplier
    GeneTex
  • Product Name
    C9orf72 antibody [GT779]
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by customer review data
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GT779
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID203228
  • Target name
    C9orf72
  • Target description
    C9orf72-SMCR8 complex subunit
  • Target synonyms
    ALSFTD; DENND9; DENNL72; FTDALS; FTDALS1; guanine nucleotide exchange C9orf72; protein C9orf72
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ96LT7
  • Protein Name
    Guanine nucleotide exchange C9orf72
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/beta-catenin pathway in C9ALS/FTD.
    Read more
  • Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models.
    Read more
  • Differential response of C9orf72 transcripts following neuronal depolarization.
    Read more
  • C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.
    Read more
  • C9ORF72 suppresses JAK-STAT mediated inflammation.
    Read more
  • An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD. Bauer CS et al., 2022 Sep, Acta Neuropathol
    Read more
  • Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice.
    Read more
  • Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models. Liu Y et al., 2021 Feb 8, Nat Commun
    Read more
  • Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. Laflamme C et al., 2019 Oct 15, Elife
    Read more