CAD (phospho Thr456) antibody

GeneTex

CAD (phospho Thr456) antibody

9

IHC-P: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

CAD

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

CDG1Z, DEE50, EIEE50, GATD4, multifunctional protein CAD, CAD trifunctional protein, carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase

Rabbit

IgG

CAD protein

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

-20°C or -80°C,2°C to 8°C

12352203