Cathepsin L antibody [33/2]

GeneTex

Cathepsin L antibody [33/2]

9

Reacts specifically with native and denatured forms of human cathepsin L and procathepsin L. Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). The antibody may be used for

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

33/2

Unconjugated

CTSL

cathepsin L

cathepsin L1; CATL; CTSL1; major excreted protein; MEP; procathepsin L

Mouse

IgG1

Cathepsins are lysosomal proteases that play an important role in the intracellular degradation of exogenous and endogenous proteins, activation of enzyme precursors, and tumor invasion and metastasis. Normally located in lysosomes of almost all mammalian cells, they can be secreted from the cell under certain conditions. Cathepsin L is responsible for most of the intra-lysosomal breakdown of normal cells. Cathepsin L is secreted by numerous transformed cells in its inactive pro-form, and mRNA expression level seems to correlate with their metastatic potential.

Human, Mink, Mouse, Rat

2°C to 8°C,-20°C or -80°C

12352203