Cathepsin L antibody [6M17]

GeneTex

Cathepsin L antibody [6M17]

9

WB: 1:500 - 1:1000. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

6M17

500 ug/ml

Unconjugated

CTSL

cathepsin L

cathepsin L1; CATL; CTSL1; major excreted protein; MEP; procathepsin L

Rat

IgG2

Cathepsin L1

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Human

-20°C or -80°C,2°C to 8°C

12352203