FACS analysis of red cell lysed human peripheral blood gated on leukocytes using GTX11089 CD3 antibody [CD3-12]. Figure A : RPE conjugated Mouse anti Human CD8 and Alexa Fluor 647 conjugated Rat IgG1 isotype control. Figure B : RPE conjugated Mouse anti Human CD8 and Alexa Fluor 647 conjugated Rat anti Human CD3 (GTX11089).
![IHC-P analysis of human tonsil tissue using GTX11089 CD3 antibody [CD3-12]. Heat mediated antigen retrieval using EDTA buffer pH9.0.](https://www.genetex.com/upload/website/prouct_img/normal/GTX11089/GTX11089_IHC-P_210118_w_23060500_242.webp "IHC-P analysis of human tonsil tissue using GTX11089 CD3 antibody [CD3-12]. Heat mediated antigen retrieval using EDTA buffer pH9.0.")
![WB analysis of Jurkat cell lysate using GTX11089 CD3 antibody [CD3-12].](https://www.genetex.com/upload/website/prouct_img/normal/GTX11089/GTX11089_WB_210118_w_23060500_740.webp "WB analysis of Jurkat cell lysate using GTX11089 CD3 antibody [CD3-12].")
FACS analysis of red cell lysed human peripheral blood gated on leukocytes using GTX11089 CD3 antibody [CD3-12]. Figure A : RPE conjugated Mouse anti Human CD8 and Alexa Fluor 647 conjugated Rat IgG1 isotype control. Figure B : RPE conjugated Mouse anti Human CD8 and Alexa Fluor 647 conjugated Rat anti Human CD3 (GTX11089).
CD3 epsilon antibody [CD3-12]
GTX11089
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityAmphibian, Avian, Bovine, Canine, Chicken, Equine, Feline, Human, Mammals, Monkey, Mouse, Porcine, Primate, Rabbit, Xenopus
TargetCD3E
Overview
- SupplierGeneTex
- Product NameCD3 epsilon antibody [CD3-12]
- Delivery Days Customer9
- Antibody SpecificityThis antibody has been specifically raised against an epitope within the epsilon peptide chain, highly conserved among species clone CD3-12 has a very broad species crossreactivity for the CD3 marker.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCD3-12
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID916
- Target nameCD3E
- Target descriptionCD3e molecule
- Target synonymsCD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3-epsilon; IMD18; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; TCRE
- HostRat
- IsotypeIgG1
- Protein IDP07766
- Protein NameT-cell surface glycoprotein CD3 epsilon chain
- Scientific DescriptionThe protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
- ReactivityAmphibian, Avian, Bovine, Canine, Chicken, Equine, Feline, Human, Mammals, Monkey, Mouse, Porcine, Primate, Rabbit, Xenopus
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
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- Intestinal microbe-dependent omega3 lipid metabolite alphaKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Nagatake T et al., 2022 Feb, Mucosal ImmunolRead more
- Cardiac macrophages prevent sudden death during heart stress. Sugita J et al., 2021 Mar 26, Nat CommunRead more
- Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice. Ling S et al., 2021 Feb, Nat Biomed EngRead more
- Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination. Kirby L et al., 2019 Aug 29, Nat CommunRead more
- Immunopotentiating effect of Inonotus obliquus fermentation products administered at vaccination in chickens. Zhang L et al., 2018 Oct, Mol Cell ProbesRead more
- Immune-mediated antitumor effect of a transplanted lymph node. Maeda T et al., 2018 Sep 1, Int J CancerRead more
- Lymphatic Reconnection and Restoration of Lymphatic Flow by Nonvascularized Lymph Node Transplantation: Real-Time Fluorescence Imaging Using Indocyanine Green and Fluorescein Isothiocyanate-Dextran. Maeda T et al., 2018 Apr, Lymphat Res BiolRead more
- Regulation of Nutritional Metabolism in Transition Dairy Cows: Energy Homeostasis and Health in Response to Post-Ruminal Choline and Methionine. Sun F et al., 2016, PLoS OneRead more