CDC27 antibody [AF3.1]
GTX10538
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Canine, Human, Mouse, Rat, Xenopus
Overview
- SupplierGeneTex
- Product NameCDC27 antibody [AF3.1]
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDAF3.1
- Concentration~2 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionCdc27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. It is a component of the Anaphase Promoting Complex (APC), which is composed of eight protein subunits and is highly conserved in eucaryotic cells. The APC catalyzes the formation of the cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis.
- ReactivityBovine, Canine, Human, Mouse, Rat, Xenopus
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A unique insertion in STARD9s motor domain regulates its stability. Senese S et al., 2015 Feb 1, Mol Biol CellRead more