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ProductsBack/Chk1 antibody [2G1D5]
WB analysis of A431 (1), HeLa (2), NIH3T3 (3) and K562 (4) cell lysate using GTX83385 Chk1 antibody [2G1D5].
WB analysis of A431 (1), HeLa (2), NIH3T3 (3) and K562 (4) cell lysate using GTX83385 Chk1 antibody [2G1D5].
WB analysis of A431 (1), HeLa (2), NIH3T3 (3) and K562 (4) cell lysate using GTX83385 Chk1 antibody [2G1D5].

Chk1 antibody [2G1D5]

GTX83385
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetCHEK1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Chk1 antibody [2G1D5]
  • Delivery Days Customer
    7
  • Application Supplier Note
    WB: 1/500 - 1/2000. ELISA: 1/10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2G1D5
  • Conjugate
    Unconjugated
  • Gene ID1111
  • Target name
    CHEK1
  • Target description
    checkpoint kinase 1
  • Target synonyms
    CHK1, OZEMA21, serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Checkpoint, S. pombe, homolog of, 1, Chk1-S, cell cycle checkpoint kinase
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDO14757
  • Protein Name
    Serine/threonine-protein kinase Chk1
  • Scientific Description
    The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Zhou L, Pei X, Zhang Y, et al. Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells. Mol Cancer Res. 2022,20(3):456-467. doi: 10.1158/1541-7786.MCR-21-0366
    Read this paper

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