IHC-P analysis of human lung tissue section using GTX20292 Collagen I antibody. Antigen retrieval : user optimized Dilution : 1:400 Localization : Strong staining was observed in the extracellular matrix of the lung. Epithelial cells were negative. Staining : antibody as precipitated red signal with a hematoxylin purple nuclear counterstain.
IHC-P analysis of human lung tissue section using GTX20292 Collagen I antibody. Antigen retrieval : user optimized Dilution : 1:400 Localization : Strong staining was observed in the extracellular matrix of the lung. Epithelial cells were negative. Staining : antibody as precipitated red signal with a hematoxylin purple nuclear counterstain.
Collagen I antibody
GTX20292
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Hamster, Human, Mouse, Rat
TargetCOL1A1
Overview
- SupplierGeneTex
- Product NameCollagen I antibody
- Delivery Days Customer9
- Antibody SpecificitySome class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues. This antibody reacts with most mammalian Type I collagens and
- Application Supplier NoteWB: 1:1000-1:10000. IHC-P: 1:50-1:200. IP: 1:100. ELISA: 1:5000-1:50000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID1277
- Target nameCOL1A1
- Target descriptioncollagen type I alpha 1 chain
- Target synonymsalpha-1 type I collagen; alpha1(I) procollagen; CAFYD; collagen alpha 1 chain type I; collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; EDSARTH1; EDSC; OI1; OI2; OI3; OI4; pro-alpha-1 collagen type 1; type I proalpha 1; type I procollagen alpha 1 chain
- HostRabbit
- IsotypeIgG
- Protein IDP02452
- Protein NameCollagen alpha-1(I) chain
- Scientific DescriptionCollagens are highly conserved throughout evolution and are characterized by an uninterrupted Glycine-X-Y triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. This preparation results in a native conformation of the protein.
- ReactivityBovine, Hamster, Human, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- TGF-beta1 Receptor Inhibitor SB525334 Attenuates the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells via the TGF-beta1 Signaling Pathway. Heo JY et al., 2021 Jul 19, BiomedicinesRead more
- Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell. Tien PT et al., 2021, Mediators InflammRead more
- Effects of TGF-beta1 Receptor Inhibitor GW788388 on the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells. Lho Y et al., 2021 Apr 29, Int J Mol SciRead more
- Bilateral sympathetic stellate ganglionectomy attenuates myocardial remodelling and fibrosis in a rat model of chronic volume overload. Zhang M et al., 2019 Feb, J Cell Mol MedRead more
- Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression. Wei CC et al., 2018 Feb, EBioMedicineRead more
- Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model. Wong K et al., 2018, Drug Des Devel TherRead more
- Autologous Adipose-Derived Tissue Matrix Part I: Biologic Characteristics. Schendel SA, 2017 Oct 1, Aesthet Surg JRead more
- Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. Chen MF et al., 2016 Jul 26, BMC CancerRead more
- The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration. Chuang HM et al., 2016, Front PharmacolRead more
- Lyso-globotriaosylceramide downregulates KCa3.1 channel expression to inhibit collagen synthesis in fibroblasts. Choi JY et al., 2015 Dec 25, Biochem Biophys Res CommunRead more