SYVN1 Antibody, FITC conjugated

Cusabio

SYVN1 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

SYVN1

synoviolin 1

DER3; E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog; HRD1; RING-type E3 ubiquitin transferase synoviolin; synovial apoptosis inhibitor 1, synoviolin

Rabbit

IgG

E3 ubiquitin-protein ligase synoviolin

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

Human

-20°C or -80°C

12352203