DCK antibody

Name: DCK antibody
SKU: GTX102800_G10
Availability: BackOrder

GTX102800

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetDCK

Overview

Supplier
GeneTex
Product Name
DCK antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.41 mg/ml
Conjugate
Unconjugated
Gene ID1633
Target name
DCK
Target description
deoxycytidine kinase
Target synonyms
deoxycytidine kinase, deoxyadenosine kinase, deoxyguanosine kinase, deoxynucleoside kinase
Host
Rabbit
Isotype
IgG
Protein IDP27707
Protein Name
Deoxycytidine kinase
Scientific Description
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Suksawat M, Klanrit P, Phetcharaburanin J, et al. In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues. PLoS One. 2019,14(9):e0222140. doi: 10.1371/journal.pone.0222140
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Sarr A, Bré J, Um IH, et al. Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031. Sci Rep. 2019,9(1):7643. doi: 10.1038/s41598-019-44089-3
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Kurata M, Rathe SK, Bailey NJ, et al. Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML. Sci Rep. 2016,6:36199. doi: 10.1038/srep36199
Read this paper