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WB analysis of HCT116 mock (Lane 1) or overexpressing DNMT3A (Lane 2) nuclear extracts using GTX30365 DNMT3A antibody. Loading : 40microg
WB analysis of HCT116 mock (Lane 1) or overexpressing DNMT3A (Lane 2) nuclear extracts using GTX30365 DNMT3A antibody. Loading : 40microg
WB analysis of HCT116 mock (Lane 1) or overexpressing DNMT3A (Lane 2) nuclear extracts using GTX30365 DNMT3A antibody. Loading : 40microg

DNMT3A antibody

Research Use Only
GTX30365
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetDNMT3A
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Overview

  • Supplier
    GeneTex
  • Product Name
    DNMT3A antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000. ICC/IF: 1:500. IHC-P: 1:200. IP: 1:10 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID1788
  • Target name
    DNMT3A
  • Target description
    DNA methyltransferase 3 alpha
  • Target synonyms
    cysteine methyltransferase DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA MTase HsaIIIA; DNMT3A2; HESJAS; M.HsaIIIA; TBRS
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9Y6K1
  • Protein Name
    DNA (cytosine-5)-methyltransferase 3A
  • Scientific Description
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Phospho-deltaNp63alpha/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. Ratovitski EA, 2014, Cell Cycle
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  • DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert MF et al., 2003 Jan, Nat Genet
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  • An essential role for DNA methyltransferase DNMT3B in cancer cell survival. Beaulieu N et al., 2002 Aug 2, J Biol Chem
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