EGFR antibody [ICR10] (PE)
GTX75350
Overview
- SupplierGeneTex
- Product NameEGFR antibody [ICR10] (PE)
- Delivery Days Customer9
- Antibody SpecificityThis antibody, clone ICR10 binds to epitope B from EGFR
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDICR10
- ConjugateRPE
- Gene ID1956
- Target nameEGFR
- Target descriptionepidermal growth factor receptor
- Target synonymsavian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor; epidermal growth factor receptor tyrosine kinase domain; ERBB; ERBB1; erb-b2 receptor tyrosine kinase 1; ERRP; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1
- HostRat
- IsotypeIgG2a
- Scientific DescriptionThe protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression. Scheidmann MC et al., 2022 Feb 15, Cancer ResRead more
- Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells. Donato C et al., 2020 Sep 8, Cell RepRead more
- Neutrophils escort circulating tumour cells to enable cell cycle progression. Szczerba BM et al., 2019 Feb, NatureRead more
- Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding. Gkountela S et al., 2019 Jan 10, CellRead more
- Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer. Vetter M et al., 2018 Nov 20, Breast Cancer ResRead more