IHC-P analysis of human breast carcinoma tissue using GTX50300 eIF2 alpha (phospho Ser51) antibody.
eIF2 alpha (phospho Ser51) antibody - Orthogonal Validated
GTX50300
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey
TargetEIF2S1
Overview
- SupplierGeneTex
- Product NameeIF2 alpha (phospho Ser51) antibody - Orthogonal Validated
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1965
- Target nameEIF2S1
- Target descriptioneukaryotic translation initiation factor 2 subunit alpha
- Target synonymsEIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eIF-2-alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionThe translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
- ReactivityHuman, Monkey
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Novel insights into PORCN mutations, associated phenotypes and pathophysiological aspects. Arlt A et al., 2022 Jan 31, Orphanet J Rare DisRead more
- Mammalian orthoreovirus Infection is Enhanced in Cells Pre-Treated with Sodium Arsenite. Lutz MM 4th et al., 2019 Jun 18, VirusesRead more
- A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine. Lee KH et al., 2014 Sep 17, Sci RepRead more