ERG Polyclonal Antibody

Elabscience

ERG Polyclonal Antibody

12

ImmunoHistoChemistry

ELISA IHC

Research Use Only

Polyclonal

0.3 mg/ml

Unconjugated

ERG

ETS transcription factor ERG

LMPHM14, erg-3, p55, transcriptional regulator ERG, ERG, ETS transcription factor, FUS/ERG fusion protein, TMPRSS2/ERG fusion, ets-related, transcriptional regulator ERG (transforming protein ERG), v-ets avian erythroblastosis virus E26 oncogene homolog, v-ets avian erythroblastosis virus E26 oncogene related, v-ets erythroblastosis virus E26 oncogene homolog, v-ets erythroblastosis virus E26 oncogene like

Rabbit

IgG

Transcriptional regulator ERG

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewings sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

-20°C

41116161