![IHC-P analysis of human endometrium (proliferation) tissue using GTX04474 Estrogen Receptor alpha antibody [MSVA-564R] HistoMAX?. Among normal tissues highest levels of estrogen receptor alpha immunostaining occur in epithelial and stromal cells of the endometrium. IHC-P analysis of human endometrium (proliferation) tissue using GTX04474 Estrogen Receptor alpha antibody [MSVA-564R] HistoMAX?. Among normal tissues highest levels of estrogen receptor alpha immunostaining occur in epithelial and stromal cells of the endometrium.](https://www.genetex.com/upload/website/prouct_img/normal/GTX04474/GTX04474_20230728_IHC-P_51_23072722_786.webp)
IHC-P analysis of human endometrium (proliferation) tissue using GTX04474 Estrogen Receptor alpha antibody [MSVA-564R] HistoMAX?. Among normal tissues highest levels of estrogen receptor alpha immunostaining occur in epithelial and stromal cells of the endometrium.
Estrogen Receptor alpha antibody [MSVA-564R] HistoMAX(tm)
GTX04474
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetESR1
Overview
- SupplierGeneTex
- Product NameEstrogen Receptor alpha antibody [MSVA-564R] HistoMAX(tm)
- Delivery Days Customer9
- Application Supplier NoteIHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMSVA-564R
- Concentration0.2 mg/ml
- ConjugateUnconjugated
- Gene ID2099
- Target nameESR1
- Target descriptionestrogen receptor 1
- Target synonymsER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor, E2 receptor alpha, ER-alpha, estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
- HostRabbit
- IsotypeIgG
- Protein IDP03372
- Protein NameEstrogen receptor
- Scientific DescriptionThis gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
![IHC-P analysis of human ectocervix tissue using GTX04474 Estrogen Receptor alpha antibody [MSVA-564R] HistoMAX?. An intense estrogen receptor alpha staining is seen in stromal cells and in the majority of squamous epithelial cells of the uterine ectocervix. IHC-P analysis of human ectocervix tissue using GTX04474 Estrogen Receptor alpha antibody [MSVA-564R] HistoMAX?. An intense estrogen receptor alpha staining is seen in stromal cells and in the majority of squamous epithelial cells of the uterine ectocervix.](https://www.genetex.com/upload/website/prouct_img/normal/GTX04474/GTX04474_20230728_IHC-P_181_23072723_568.webp)
![IHC-P analysis of human endometrioid carcinoma (EC) tissue using GTX04474 Estrogen Receptor alpha antibody [MSVA-564R] HistoMAX?. Endometroid carcinoma of the ovary with strong estrogen receptor alpha immunostaining of all tumor cells. IHC-P analysis of human endometrioid carcinoma (EC) tissue using GTX04474 Estrogen Receptor alpha antibody [MSVA-564R] HistoMAX?. Endometroid carcinoma of the ovary with strong estrogen receptor alpha immunostaining of all tumor cells.](https://www.genetex.com/upload/website/prouct_img/normal/GTX04474/GTX04474_20230728_IHC-P_311_23072723_717.webp)


![Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Estrogen Receptor alpha antibody [SC1] (GTX02805) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.](https://www.genetex.com/upload/website/prouct_img/normal/GTX02805/GTX02805_20201204_WB_w_23053122_604.webp)
![ChIP analysis of sheared chromatin from MCF7 cells treated for 1 hour with estradiol using GTX60340 Estrogen Receptor alpha antibody [GT9004]. The IP'd DNA was analysed with an Illumina Genome Analyzer. Library preparation, cluster generation and sequencing were performed according to the manufacturer's instructions. The 36 bp tags were aligned to the human genome using the ELAND algorithm. This figure shows the obtained peaks near the TFF1 gene on chromosome 21 (figure 1A), the GREB1 and HAAO genes on chromosome 2 (figure 1B and C), and the ZNF185 gene on the X-chromosome (figure 1D).](https://www.genetex.com/upload/website/prouct_img/normal/GTX60340/GTX60340_20201117_ChIP_64_w_23061123_131.webp)
![Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membranes were blotted with Estrogen Receptor alpha antibody [HL1081] (GTX636202) diluted at 1:1000 and competitor's antibody (Competitor) diluted at 1:100. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced. *The competitor is not affiliated with GeneTex and does not endorse this product.](https://www.genetex.com/upload/website/prouct_img/normal/GTX636202/GTX636202_44480_20220812_WB_competitor_watermark_22081423_461.webp)
![Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membranes were blotted with Estrogen Receptor alpha antibody [HL1082] (GTX636203) diluted at 1:1000 and competitor's antibody (Competitor) diluted at 1:100. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced. *The competitor is not affiliated with GeneTex and does not endorse this product.](https://www.genetex.com/upload/website/prouct_img/normal/GTX636203/GTX636203_44382_20220812_WB_competitor_watermark_22081423_456.webp)
