Estrogen Receptor beta antibody [6A12]
GTX70178
ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
TargetESR2
Overview
- SupplierGeneTex
- Product NameEstrogen Receptor beta antibody [6A12]
- Delivery Days Customer9
- Application Supplier NoteWB: 1 - 5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID6A12
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID2100
- Target nameESR2
- Target descriptionestrogen receptor 2
- Target synonymsErb; ER-BETA; ESRB; ESR-BETA; ESTRB; estrogen receptor beta; estrogen receptor beta 4; estrogen receptor beta splice variant, ERbeta2delta7; estrogen receptor beta splice variant, ERbeta4delta7; estrogen receptor beta splice variant, ERbeta6; estrogen receptor beta splice variant, ERbeta6delta7; estrogen receptor beta splice variant, ERbeta7; estrogen receptor beta splice variant, ERbeta7delta7; estrogen receptor beta splice variant, ERbetaEx. 4L; estrogen receptor beta splice variant, ERbetaEx. 6L; NR3A2; nuclear receptor subfamily 3 group A member 2; ODG8; oestrogen receptor beta
- HostMouse
- IsotypeIgG2a
- Protein IDQ92731
- Protein NameEstrogen receptor beta
- Scientific DescriptionThis gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Estrogen receptor beta causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Paruthiyil S et al., 2011 Oct, Breast Cancer Res TreatRead more
- Estrogen receptor beta binds to and regulates three distinct classes of target genes. Vivar OI et al., 2010 Jul 16, J Biol ChemRead more
- Selective activation of estrogen receptor-beta target genes by 3,3-diindolylmethane. Vivar OI et al., 2010 Apr, EndocrinologyRead more
- Activity and intracellular location of estrogen receptors alpha and beta in human bronchial epithelial cells. Ivanova MM et al., 2009 Jun 16, Mol Cell EndocrinolRead more
- Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. Klinge CM et al., 2008 Jul, FASEB JRead more
- Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Cvoro A et al., 2007 Feb, EndocrinologyRead more
- Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Cvoro A et al., 2006 Feb 17, Mol CellRead more
- Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Tee MK et al., 2004 Mar, Mol Biol CellRead more
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