Estrogen Receptor beta antibody [7B10.7]
GTX70182
ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation
Product group Antibodies
TargetESR2
Overview
- SupplierGeneTex
- Product NameEstrogen Receptor beta antibody [7B10.7]
- Delivery Days Customer9
- Application Supplier NoteWB: 1 - 5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID7B10.7
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID2100
- Target nameESR2
- Target descriptionestrogen receptor 2
- Target synonymsErb; ER-BETA; ESRB; ESR-BETA; ESTRB; estrogen receptor beta; estrogen receptor beta 4; estrogen receptor beta splice variant, ERbeta2delta7; estrogen receptor beta splice variant, ERbeta4delta7; estrogen receptor beta splice variant, ERbeta6; estrogen receptor beta splice variant, ERbeta6delta7; estrogen receptor beta splice variant, ERbeta7; estrogen receptor beta splice variant, ERbeta7delta7; estrogen receptor beta splice variant, ERbetaEx. 4L; estrogen receptor beta splice variant, ERbetaEx. 6L; NR3A2; nuclear receptor subfamily 3 group A member 2; ODG8; oestrogen receptor beta
- HostMouse
- IsotypeIgG1
- Protein IDQ92731
- Protein NameEstrogen receptor beta
- Scientific DescriptionThis gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Insights into the Role of Estrogen Receptor beta in Triple-Negative Breast Cancer. Sellitto A et al., 2020 Jun 5, Cancers (Basel)Read more
- Estrogen Receptor-beta Modulation of the ERalpha-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer. Lu W et al., 2017 Aug, Horm CancerRead more
- Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity. Nelson AW et al., 2017 Jan 15, Mol Cell EndocrinolRead more
- Estrogen receptor beta regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation. Monsivais D et al., 2016 May, Fertil SterilRead more
- ERbeta- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Monsivais D et al., 2014 Aug, Mol EndocrinolRead more
- Preferential estrogen receptor beta ligands reduce Bcl-2 expression in hormone-resistant breast cancer cells to increase autophagy. Ruddy SC et al., 2014 Jul, Mol Cancer TherRead more
- Mechanisms enforcing the estrogen receptor beta selectivity of botanical estrogens. Jiang Y et al., 2013 Nov, FASEB JRead more
- Integrative genomics of gene and metabolic regulation by estrogen receptors alpha and beta, and their coregulators. Madak-Erdogan Z et al., 2013 Jun 18, Mol Syst BiolRead more
- Induction of quinone reductase by tamoxifen or DPN protects against mammary tumorigenesis. Krishnamurthy N et al., 2012 Oct, FASEB JRead more
- Estrogen receptor beta causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Paruthiyil S et al., 2011 Oct, Breast Cancer Res TreatRead more
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