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ProductsBack/Ganglioside GT1b . trisodium salt (bovine brain) [59247-13-1]

Ganglioside GT1b . trisodium salt (bovine brain) [59247-13-1]

Research Use Only
AG-CN2-9006
AdipoGen Life Sciences
CAS Number59247-13-1
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid)
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ganglioside GT1b . trisodium salt (bovine brain)
  • Delivery Days Customer
    10
  • CAS Number
    59247-13-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C95H162N5O47 . 3Na
  • Molecular Weight
    2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid)
  • Scientific Description
    Chemical. CAS: 59247-13-1. Formula: C95H162N5O47 . 3Na. MW: 2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid). Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GT1b binds botulinum and tetanus neurotoxins and it prevents neurotoxicity of glutamate on neuronal cells. - Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GT1b binds botulinum and tetanus neurotoxins and it prevents neurotoxicity of glutamate on neuronal cells.
  • SMILES
    [Na+].[Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@H]1[C@H](O)C(CO)O[C@@H](OC2[C@@H](O)[C@H](CO)O[C@H](O[C@H]3C(CO)O[C@@H](O[C@H]4C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC)O[C@H]4CO)C(O)[C@H]3O[C@@]3(CC(O)[C@@H](NC(C)=O)C(O3)[C@@]([H])(O)[C@]([H])(CO)O[C@@]3(CC(O)[C@@H](NC(C)=O)C(O3)[C@@]([H])(O)[C@]([H])(O)CO)C([O-])=O)C([O-])=O)C2NC(C)=O)C1O)C([O-])=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982).
  • Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereof: C.L. Schengrund, et al.; J. Neurochem. 57, 1024 (1991)
  • Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)
  • Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells: S. Watanabe, et al.; Neurosci. Lett. 517, 140 (2012)