GCLC antibody [N1N3]
GTX113197
Overview
- SupplierGeneTex
- Product NameGCLC antibody [N1N3]
- Delivery Days Customer9
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID2729
- Target nameGCLC
- Target descriptionglutamate-cysteine ligase catalytic subunit
- Target synonymsgamma-ECS; gamma-glutamylcysteine synthetase; GCL; GCS; GCS heavy chain; GLCL; GLCLC; glutamate--cysteine ligase catalytic subunit
- HostRabbit
- IsotypeIgG
- Protein IDP48506
- Protein NameGlutamate--cysteine ligase catalytic subunit
- Scientific DescriptionGlutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation. Bai X et al., 2019, Oxid Med Cell LongevRead more
- H2O2 induces caveolin-1 degradation and impaired mitochondrial function in E11 podocytes. Chen YH et al., 2017 Nov, Mol Med RepRead more