Girdin antibody

GeneTex

Girdin antibody

9

WB: 1 - 2 microg/mL. IHC-P: 20 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

CCDC88A

coiled-coil domain containing 88A

AKT-phosphorylation enhancer; APE; g alpha-interacting vesicle-associated protein; girders of actin filaments; girdin; GIV; GRDN; HkRP1; Hook-related protein 1; KIAA1212; PEHO; PEHOL

Rabbit

IgG

Girdin

Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203