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Glutamine synthetase antibody [GT1055]

GTX630654
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetGLUL
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Overview

  • Supplier
    GeneTex
  • Product Name
    Glutamine synthetase antibody [GT1055]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GT1055
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2752
  • Target name
    GLUL
  • Target description
    glutamate-ammonia ligase
  • Target synonyms
    cell proliferation-inducing protein 59; GLNS; glutamate decarboxylase; glutamine synthase; glutamine synthetase; GS; palmitoyltransferase GLUL; PIG43; PIG59; proliferation-inducing protein 43
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP15104
  • Protein Name
    Glutamine synthetase
  • Scientific Description
    Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling (Haberle et al., 2005 [PubMed 16267323]). Fetal glutamine requirements are very high and depend largely on active glutamine synthesis and the release of glutamine into the fetal circulation by the placenta. Glutamine synthetase (EC 6.3.1.2), also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses (see references in Clancy et al., 1996 [PubMed 8975719]).[supplied by OMIM]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells. Jhu JW et al., 2021 Sep 10, Int J Mol Sci
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  • Additional Inhibition of Wnt/beta-Catenin Signaling by Metformin in DAA Treatments as a Novel Therapeutic Strategy for HCV-Infected Patients. Lin D et al., 2021 Apr 2, Cells
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  • d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production. Seki T et al., 2018 Dec, Mol Cell Neurosci
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