Glutamine synthetase antibody
![Research Use Only](static/images/certificates/ruo.jpg)
GTX109121
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat, Zebra Fish
TargetGLUL
Overview
- SupplierGeneTex
- Product NameGlutamine synthetase antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.16 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID2752
- Target nameGLUL
- Target descriptionglutamate-ammonia ligase
- Target synonymscell proliferation-inducing protein 59; GLNS; glutamate decarboxylase; glutamine synthase; glutamine synthetase; GS; palmitoyltransferase GLUL; PIG43; PIG59; proliferation-inducing protein 43
- HostRabbit
- IsotypeIgG
- Protein IDP15104
- Protein NameGlutamine synthetase
- Scientific DescriptionGlutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling (Haberle et al., 2005 [PubMed 16267323]). Fetal glutamine requirements are very high and depend largely on active glutamine synthesis and the release of glutamine into the fetal circulation by the placenta. Glutamine synthetase (EC 6.3.1.2), also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses (see references in Clancy et al., 1996 [PubMed 8975719]).[supplied by OMIM]
- ReactivityHuman, Mouse, Rat, Zebra Fish
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinsons disease. Iovino L et al., 2022 Jul, Acta NeuropatholRead more
- Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation. Gallego-Duran R et al., 2022 Mar 1, Sci RepRead more
- TRPV4-induced Mueller cell gliosis and TNF-alpha elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-kappaB pathway. Li Q et al., 2021 Nov 17, J NeuroinflammationRead more
- Microglia-Derived Small Extracellular Vesicles Reduce Glioma Growth by Modifying Tumor Cell Metabolism and Enhancing Glutamate Clearance through miR-124. Serpe C et al., 2021 Aug 12, CellsRead more
- Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival. Schmidt A et al., 2021 Nov, J Cancer Res Clin OncolRead more
- Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas. Wang H et al., 2021, Cell Mol Gastroenterol HepatolRead more
- Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation. Yamada T et al., 2020, Front PhysiolRead more
- A spatial similarity of stereochemical environments formed by amino acid residues defines a common epitope of two non-homologous proteins. Nakashima K et al., 2019 Oct 15, Sci RepRead more
- Lithium and glutamine synthetase: Protective effects following stress. Mundorf A et al., 2019 Nov, Psychiatry ResRead more
- Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury. Pronin A et al., 2019, Front Mol NeurosciRead more