GRK2 (phospho Ser670) antibody
GTX130007
Overview
- SupplierGeneTex
- Product NameGRK2 (phospho Ser670) antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID156
- Target nameGRK2
- Target descriptionG protein-coupled receptor kinase 2
- Target synonymsADRBK1; adrenergic beta receptor kinase 1; BARK1; beta-adrenergic receptor kinase 1; BETA-ARK1; beta-ARK-1
- HostRabbit
- IsotypeIgG
- Protein IDP25098
- Protein NameBeta-adrenergic receptor kinase 1
- Scientific DescriptionThe product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- LDK378 inhibits the recruitment of myeloid-derived suppressor cells to spleen via the p38-GRK2-CCR2 pathway in mice with sepsis. Hu J et al., 2019 Nov, Immunol Cell BiolRead more
- Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes. Taguchi K et al., 2018 Apr, Hypertens ResRead more