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ProductsBack/Hec1 antibody

Hec1 antibody

Research Use Only
GTX110735
GeneTex
ApplicationsImmunoPrecipitation, Western Blot
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetNDC80
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Overview

  • Supplier
    GeneTex
  • Product Name
    Hec1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.46 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID10403
  • Target name
    NDC80
  • Target description
    NDC80 kinetochore complex component
  • Target synonyms
    HEC; HEC1; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2; KNTC2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; retinoblastoma-associated protein HEC; TID3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO14777
  • Protein Name
    Kinetochore protein NDC80 homolog
  • Scientific Description
    HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells. Liu YH et al., 2018 Jul 15, Phytomedicine
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  • Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties. Lee YS et al., 2014 May 22, J Med Chem
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  • Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1. Huang LY et al., 2014 Jan 9, J Exp Clin Cancer Res
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