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ProductsBack/Hec1 (phospho Ser 165) antibody

Hec1 (phospho Ser 165) antibody

GTX70013
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mammals, Mouse, Rat
TargetNDC80
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Overview

  • Supplier
    GeneTex
  • Product Name
    Hec1 (phospho Ser 165) antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    Recommended Starting Dilutions:For WB: Use at a dilution of 1:300For ICC/IF: Use at a dilution of 1:150Not yet tested in other applications. Optimal dilutions should be determined experimentally by the researcher.
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.13 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10403
  • Target name
    NDC80
  • Target description
    NDC80 kinetochore complex component
  • Target synonyms
    HEC; HEC1; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2; KNTC2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; retinoblastoma-associated protein HEC; TID3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO14777
  • Protein Name
    Kinetochore protein NDC80 homolog
  • Scientific Description
    This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
  • Reactivity
    Human, Mammals, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity. Fang Y et al., 2016 Nov 29, Oncotarget
    Read more
  • Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint. Wei R et al., 2011 Oct, Mol Biol Cell
    Read more