HGS Antibody

Cusabio

HGS Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

HGS

hepatocyte growth factor-regulated tyrosine kinase substrate

HRS, hepatocyte growth factor-regulated tyrosine kinase substrate, human growth factor-regulated tyrosine kinase substrate, protein pp110

Rabbit

IgG

Hepatocyte growth factor-regulated tyrosine kinase substrate

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. Asao H., J. Biol. Chem. 272:32785-32791(1997). Lu L., Gene 213:125-132(1998). Scoles D.R., Hum. Mol. Genet. 9:1567-1574(2000).

Human, Mouse, Rat

-20°C or -80°C

41116161