HMGB3 Antibody, FITC conjugated

Cusabio

HMGB3 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

HMGB3

high mobility group box 3

HMG-2a, HMG-4, HMG2A, HMG4, high mobility group protein B3, high mobility group protein 2a, high-mobility group (nonhistone chromosomal) protein 4

Rabbit

IgG

High mobility group protein B3

Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity).

Human

-20°C or -80°C

41116161