Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using HMGCS1 Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using HMGCS1 Polyclonal Antibody at dilution 1:40
HMGCS1 Polyclonal Antibody
E-AB-16482
Product group Antibodies
Overview
- SupplierElabscience
- Product NameHMGCS1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.6mg/ml
- Scientific DescriptionHMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
- UNSPSC12352203