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Hsp90 beta antibody

GTX101448
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat, Zebra Fish
TargetHSP90AB1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Hsp90 beta antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3326
  • Target name
    HSP90AB1
  • Target description
    heat shock protein 90 alpha family class B member 1
  • Target synonyms
    D6S182, HSP84, HSP90B, HSPC2, HSPCB, heat shock protein HSP 90-beta, HSP90-beta, heat shock 84 kDa, heat shock 90kD protein 1, beta, heat shock protein 90 kDa, heat shock protein 90kDa alpha (cytosolic), class B member 1, heat shock protein 90kDa alpha family class B member 1, heat shock protein family C member 3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP08238
  • Protein Name
    Heat shock protein HSP 90-beta
  • Scientific Description
    HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]
  • Reactivity
    Human, Mouse, Rat, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Lu SH, Wu YH, Su LY, et al. Cardiac myofibrillogenesis is spatiotemporally modulated by the molecular chaperone UNC45B. Stem Cell Reports. 2023,18(7):1405-1420. doi: 10.1016/j.stemcr.2023.05.006
    Read this paper
  • Navare AT, Mast FD, Olivier JP, et al. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. J Cell Biol. 2022,221(11). doi: 10.1083/jcb.202011050
    Read this paper
  • Morrow CS, Arndt ZP, Klosa PC, et al. Adult fibroblasts use aggresomes only in distinct cell-states. Sci Rep. 2022,12(1):15001. doi: 10.1038/s41598-022-19055-1
    Read this paper
  • Navare AT, Mast FD, Olivier JP, et al. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. bioRxiv. 2020,221(11):pii: 2020.10.12.336487. doi: 10.1101/2020.10.12.336487.
    Read this paper
  • Ono K, Sogawa C, Kawai H, et al. Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer. J Extracell Vesicles. 2020,9(1):1769373. doi: 10.1080/20013078.2020.1769373
    Read this paper
  • Lee EJ, Chiang WJ, Kroeger H, et al. Multiexon deletion alleles of ATF6 linked to achromatopsia. JCI Insight. 2020,5(7):pii: 136041. doi: 10.1172/jci.insight.136041.
    Read this paper
  • Eguchi T, Sogawa C, Ono K, et al. Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells. Cells. 2020,9(3). doi: 10.3390/cells9030755
    Read this paper
  • Fujiwara T, Eguchi T, Sogawa C, et al. Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab. Oral Oncol. 2018,86:251-257. doi: 10.1016/j.oraloncology.2018.09.030
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  • Jividen K, Kedzierska KZ, Yang CS, et al. Genomic analysis of DNA repair genes and androgen signaling in prostate cancer. BMC Cancer. 2018,18(1):960. doi: 10.1186/s12885-018-4848-x
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  • Fujiwara T, Eguchi T, Sogawa C, et al. Anti-EGFR antibody cetuximab is secreted by oral squamous cell carcinoma and alters EGF-driven mesenchymal transition. Biochem Biophys Res Commun. 2018,503(3):1267-1272. doi: 10.1016/j.bbrc.2018.07.035
    Read this paper