IGF1R alpha antibody [AMY10-105.8 (1H7)]

GeneTex

IGF1R antibody [AMY10-105.8 (1H7)]

9

This antibody recognizes an epitope in the alpha subunits of IGF1R. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to IGF1 Receptor (Li et al.1993).

Neutralizing/Inhibition: . *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, Neutralisation/Blocking

Research Use Only

Monoclonal

AMY10-105.8 (1H7)

Unconjugated

IGF1R

insulin like growth factor 1 receptor

CD221; IGF-I receptor; IGFIR; IGFR; insulin-like growth factor 1 receptor; JTK13; soluble IGF1R variant 1; soluble IGF1R variant 2

Mouse

IgG1

Insulin-like growth factor 1 receptor

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Human

-20°C or -80°C,2°C to 8°C

12352203