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ProductsBack/IGF2R antibody [MEM-238]
Fig. 1. Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. Lane 1: immunostaining with anti-CD222 [MEM-238] Lane 2: immunostaining with Isotype mouse IgG1 control
Fig. 1. Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. Lane 1: immunostaining with anti-CD222 [MEM-238] Lane 2: immunostaining with Isotype mouse IgG1 control
Fig. 1. Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. Lane 1: immunostaining with anti-CD222 [MEM-238] Lane 2: immunostaining with Isotype mouse IgG1 control

IGF2R antibody [MEM-238]

GTX28093
GeneTex
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Primate
TargetIGF2R
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Overview

  • Supplier
    GeneTex
  • Product Name
    IGF2R antibody [MEM-238]
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody recognizes an epitope between amino acids 192-697 of CD222 (IGF2 receptor).
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    MEM-238
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3482
  • Target name
    IGF2R
  • Target description
    insulin like growth factor 2 receptor
  • Target synonyms
    300 kDa mannose 6-phosphate receptor; cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; CI-M6PR; CIMPR; IGF-II receptor; insulin-like growth factor II receptor; M6P/IGF2 receptor; M6P/IGF2R; M6P-R; MPR 300; MPR1; MPR300; MPRI
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP11717
  • Protein Name
    Cation-independent mannose-6-phosphate receptor
  • Scientific Description
    This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
  • Reactivity
    Human, Mouse, Primate
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • The role of insulin-like growth factor in Acrochordon Etiopathology. Koeseoglu HG et al., 2020 Nov 3, BMC Dermatol
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  • Adjunctive albuterol enhances the response to enzyme replacement therapy in late-onset Pompe disease. Koeberl DD et al., 2014 May, FASEB J
    Read more
  • Adjunctive beta2-agonists reverse neuromuscular involvement in murine Pompe disease. Li S et al., 2013 Jan, FASEB J
    Read more
  • Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle. Koeberl DD et al., 2011 Jun, Mol Genet Metab
    Read more