IL1 Receptor 2 antibody
GTX27748
Overview
- SupplierGeneTex
- Product NameIL1 Receptor 2 antibody
- Delivery Days Customer10
- ApplicationsOther Application
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.1 mg/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe IL-1 system includes two agonists (IL-1a and IL-1b), converting enzymes, antagonists, two receptors (IL-1 RI and IL-1 RII) and the IL-1 receptor accessory protein. The IL-1 RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signaling IL-1 RI. The decoy IL-1 RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by co-receptor competition. Further a soluble form of IL-1 RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203