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ProductsBack/Jab1 antibody [8H8.5]

Jab1 antibody [8H8.5]

GTX70207
GeneTex
ApplicationsImmunoPrecipitation, Western Blot
Product group Antibodies
TargetCOPS5
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Overview

  • Supplier
    GeneTex
  • Product Name
    Jab1 antibody [8H8.5]
  • Delivery Days Customer
    9
  • Applications
    ImmunoPrecipitation, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    8H8.5
  • Conjugate
    Unconjugated
  • Gene ID10987
  • Target name
    COPS5
  • Target description
    COP9 signalosome subunit 5
  • Target synonyms
    CSN5, JAB1, MOV-34, SGN5, COP9 signalosome complex subunit 5, 38 kDa Mov34 homolog, COP9 constitutive photomorphogenic homolog subunit 5, jun activation domain-binding protein 1, signalosome subunit 5, testis secretory sperm-binding protein Li 231m
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDQ92905
  • Protein Name
    COP9 signalosome complex subunit 5
  • Scientific Description
    The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Dubiel D, Wang J, Hartig R, et al. Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18. iScience. 2023,26(4):106468. doi: 10.1016/j.isci.2023.106468
    Read this paper
  • Jantaree P, Chaithongyot S, Sokolova O, et al. USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection. Cell Mol Life Sci. 2022,79(8):461. doi: 10.1007/s00018-022-04489-7
    Read this paper
  • Chen J, Shin JH, Zhao R, et al. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014,5:5384. doi: 10.1038/ncomms6384
    Read this paper
  • Feist M, Huang X, Müller JM, et al. Can hyperthermic intraperitoneal chemotherapy efficiency be improved by blocking the DNA repair factor COP9 signalosome? Int J Colorectal Dis. 2014,29(6):673-80. doi: 10.1007/s00384-014-1861-7
    Read this paper
  • Mitsuhashi T, Yonemoto J, Sone H, et al. In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1. Proc Natl Acad Sci U S A. 2010,107(37):16331-5. doi: 10.1073/pnas.1002960107
    Read this paper
  • da Silva Correia J, Miranda Y, Leonard N, et al. The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. J Biol Chem. 2007,282(17):12557-65.
    Read this paper
  • Burger-Kentischer A, Finkelmeier D, Thiele M, et al. Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif. FEBS Lett. 2005,579(7):1693-701.
    Read this paper
  • Doronkin S, Djagaeva I, Beckendorf SK. The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis. Dev Cell. 2003,4(5):699-710.
    Read this paper

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Figure 1. Western blot analysis of JAB1 using anti-JAB1 antibody (PB9490). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human Raji whole cell lysates, Lane 2: human K562 whole cell lysates, Lane 3: human PC-3 whole cell lysates, Lane 4: human Hela whole cell lysates, Lane 5: human A549 whole cell lysates, Lane 6: human HEK293 whole cell lysates, Lane 7: rat brain tissue lysates, Lane 8: rat heart tissue lysates, Lane 9: mouse brain tissue lysates, Lane 10: mouse heart tissue lysates, Lane 11: mouse SP2/0 whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-JAB1 antigen affinity purified polyclonal antibody (Catalog # PB9490) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for JAB1 at approximately 38 kDa. The expected band size for JAB1 is at 38 kDa.
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