Jab1 antibody [8H8.5]
GTX70207
ApplicationsImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityDrosophila, Human, Mouse
TargetCOPS5
Overview
- SupplierGeneTex
- Product NameJab1 antibody [8H8.5]
- Delivery Days Customer9
- ApplicationsImmunoPrecipitation, Western Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID8H8.5
- ConjugateUnconjugated
- Gene ID10987
- Target nameCOPS5
- Target descriptionCOP9 signalosome subunit 5
- Target synonyms38 kDa Mov34 homolog; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; jun activation domain-binding protein 1; MOV-34; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
- HostMouse
- IsotypeIgG2a
- Protein IDQ92905
- Protein NameCOP9 signalosome complex subunit 5
- Scientific DescriptionThe protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
- ReactivityDrosophila, Human, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18.Read more
- USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection.Read more
- CSN6 drives carcinogenesis by positively regulating Myc stability. Chen J et al., 2014 Nov 14, Nat CommunRead more
- Can hyperthermic intraperitoneal chemotherapy efficiency be improved by blocking the DNA repair factor COP9 signalosome? Feist M et al., 2014 Jun, Int J Colorectal DisRead more
- In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1. Mitsuhashi T et al., 2010 Sep 14, Proc Natl Acad Sci U S ARead more
- The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. da Silva Correia J et al., 2007 Apr 27, J Biol ChemRead more
- Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif. Burger-Kentischer A et al., 2005 Mar 14, FEBS LettRead more
- The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis. Doronkin S et al., 2003 May, Dev CellRead more