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Chemical Structure
Chemical Structure
Chemical Structure

Kaempferitrin [482-38-2]

Research Use Only
AG-CN2-0039
AdipoGen Life Sciences
CAS Number482-38-2
Product group Chemicals
Estimated Purity>98% (NMR)
Molecular Weight578.5
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Kaempferitrin [482-38-2]
  • Delivery Days Customer
    10
  • CAS Number
    482-38-2
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (NMR)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C27H30O14
  • Molecular Weight
    578.5
  • Scientific Description
    Chemical. CAS: 482-38-2. Formula: C27H30O14. MW: 578.5. Isolated from Cinnamomum sp. Cytotoxic and anti-inflammatory compound (weak). Antioxidant. Lipid peroxidation inhibitor. Free radical scavenger. Inhibitor of myeloperoxidase activity. Hypoglycemic. Decreases blood glucose levels in diabetic and normal rats. Insulinomimetic. Modulates glucose homeostasis. Decreases blood glucose levels and stimulates glucose uptake in muscle. Inhibits GLUT4 mediated glucose uptake in differentiated 3T3-L1 cells. Improves insulin resistance by the activation of the classical insulin transduction pathway. Increases adiponectin secretion in 3T3-L1 adipocytes. Antinoniceptive. May have antidyslipidemic activity. - Cytotoxic and anti-inflammatory compound (weak) [1, 4, 8, 10, 11]. Antioxidant [2, 5]. Lipid peroxidation inhibitor [2, 5]. Free radical scavenger [2, 5]. Inhibitor of myeloperoxidase activity [2, 5]. Hypoglycemic. Decreases blood glucose levels in diabetic and normal rats [2, 3]. Insulinomimetic. Modulates glucose homeostasis [12]. Decreases blood glucose levels and stimulates glucose uptake in muscle [3]. Inhibits GLUT4 mediated glucose uptake in differentiated 3T3-L1 cells [6]. Improves insulin resistance by the activation of the classical insulin transduction pathway [7]. Increases adiponectin secretion in 3T3-L1 adipocytes [7]. Antinoniceptive [8]. May have antidyslipidemic activity [9].
  • SMILES
    O=C1C2=C(O)C=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C=C2OC(C4=CC=C(O)C=C4)=C1O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Kaempferitrin from the leaves of Hedyotis verticillata and its biological activity: A.S. Hamzah, et al.; Planta Med. 60, 388 (1994)
  • Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves: E. de Sousa, et al.; J. Nat. Prod. 67, 829 (2004)
  • Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle: A.P. Jorge, et al.; Chem. Biol. Interact. 149, 89 (2004)
  • Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-gamma-activated murine macrophages: S.H. Fang, et al.; Bioorg. Med. Chem. 13, 2381 (2005)
  • Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors: L.O. Regasini, et al.; Phytochemistry 69, 1739 (2008)
  • Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes: C.N. Vishnu Prasad, et al.; BBRC 380, 39 (2009)
  • Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes: Y.M. Tzeng, et al.; Eur. J. Pharmacol. 607, 27 (2009)
  • Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum: G.O. De Melo, et al.; J. Ethnopharmacol. 124, 228 (2009)
  • Antidyslipidemic Activity of Hot-water Extracts from Leaves of Cinnamomum osmophloeum Kaneh: T.Y. Lin, et al.; Phytother. Res. 25, 1317 (2011)
  • Lotus corniculatus regulates the inflammation induced by bradykinin in a murine model of pleurisy: D.A. Pereira, et al.; J. Agric. Food Chem. 59, 2291 (2011)