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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA618886LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA618886LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA618886LA01HU at dilution of 1:100

LRRC32 Antibody

CSB-PA618886LA01HU
Cusabio
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetLRRC32
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Overview

  • Supplier
    Cusabio
  • Product Name
    LRRC32 Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID2615
  • Target name
    LRRC32
  • Target description
    leucine rich repeat containing 32
  • Target synonyms
    CPPRDD, D11S833E, GARP, transforming growth factor beta activator LRRC32, garpin, glycoprotein A repetitions predominant, leucine-rich repeat-containing protein 32
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ14392
  • Protein Name
    Transforming growth factor beta activator LRRC32
  • Scientific Description
    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    41116161