ProductsBack/LXR beta antibody [N2C2], Internal

LXR beta antibody [N2C2], Internal

Name: LXR beta antibody [N2C2], Internal
SKU: GTX113571_G10
Availability: BackOrder

GTX113571

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman, Mouse

TargetNR1H2

Overview

Supplier
GeneTex
Product Name
LXR beta antibody [N2C2], Internal
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID7376
Target name
NR1H2
Target description
nuclear receptor subfamily 1 group H member 2
Target synonyms
LXR-b, LXRB, NER, NER-I, RIP15, UNR, oxysterols receptor LXR-beta, LX receptor beta, liver X nuclear receptor beta, nuclear orphan receptor LXR-beta, nuclear receptor NER, steroid hormone-nuclear receptor NER, ubiquitously-expressed nuclear receptor
Host
Rabbit
Isotype
IgG
Protein IDP55055
Protein Name
Oxysterols receptor LXR-beta
Scientific Description
The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM]
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

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Spagnuolo MS, Donizetti A, Iannotta L, et al. Brain-derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons. J Cell Physiol. 2018,233(9):6925-6943. doi: 10.1002/jcp.26480
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Gui Y, Yao S, Yan H, et al. A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice. Cardiovasc Res. 2016,112(1):502-14. doi: 10.1093/cvr/cvw183
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Gui YZ, Yan H, Gao F, et al. Betulin attenuates atherosclerosis in apoE(-/-) mice by up-regulating ABCA1 and ABCG1. Acta Pharmacol Sin. 2016,37(10):1337-1348. doi: 10.1038/aps.2016.46
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Ma GC, Wu PF, Tseng HC, et al. Inhibitory effect of Piper betel leaf extracts on copper-mediated LDL oxidation and oxLDL-induced lipid accumulation via inducing reverse cholesterol transport in macrophages. Food Chem. 2013,141(4):3703-13. doi: 10.1016/j.foodchem.2013.06.003
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