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WB analysis of human bone marrow lysate using GTX89661 LXR beta antibody, N-term. Dilution : 1microg/ml Loading : 35microg protein in RIPA buffer
WB analysis of human bone marrow lysate using GTX89661 LXR beta antibody, N-term. Dilution : 1microg/ml Loading : 35microg protein in RIPA buffer
WB analysis of human bone marrow lysate using GTX89661 LXR beta antibody, N-term. Dilution : 1microg/ml Loading : 35microg protein in RIPA buffer

LXR beta antibody, N-term

GTX89661
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
TargetNR1H2
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Overview

  • Supplier
    GeneTex
  • Product Name
    LXR beta antibody, N-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1-3microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.50 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7376
  • Target name
    NR1H2
  • Target description
    nuclear receptor subfamily 1 group H member 2
  • Target synonyms
    liver X nuclear receptor beta; LX receptor beta; LXRB; LXR-b; NER; NER-I; nuclear orphan receptor LXR-beta; nuclear receptor NER; oxysterols receptor LXR-beta; RIP15; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor; UNR
  • Host
    Goat
  • Isotype
    IgG
  • Protein IDP55055
  • Protein Name
    Oxysterols receptor LXR-beta
  • Scientific Description
    The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. Candelaria NR et al., 2014, PLoS One
    Read more
  • Liver X receptor beta protects dopaminergic neurons in a mouse model of Parkinson disease. Dai YB et al., 2012 Aug 7, Proc Natl Acad Sci U S A
    Read more

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Figure 1. Western blot analysis of LXR beta/NER/NR1H2 using anti-LXR beta/NER/NR1H2 antibody (A04523-2). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human PC-3 whole cell lysates, Lane 2: human HL-60 whole cell lysates, Lane 3: mouse liver tissue lysates, Lane 4: mouse RAW264.7 whole cell lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-LXR beta/NER/NR1H2 antigen affinity purified polyclonal antibody (Catalog # A04523-2) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for LXR beta/NER/NR1H2 at approximately 50KD. The expected band size for LXR beta/NER/NR1H2 is at 50KD.
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