
WB analysis of human bone marrow lysate using GTX89661 LXR beta antibody, N-term. Dilution : 1microg/ml Loading : 35microg protein in RIPA buffer
LXR beta antibody, N-term
GTX89661
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetNR1H2
Overview
- SupplierGeneTex
- Product NameLXR beta antibody, N-term
- Delivery Days Customer9
- Antibody SpecificityBased on the peptide used, this antibody is expected to be specific for LXR beta and not to cross-react with LXR alpha.
- Application Supplier NoteWB: 1-3microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- Gene ID7376
- Target nameNR1H2
- Target descriptionnuclear receptor subfamily 1 group H member 2
- Target synonymsliver X nuclear receptor beta; LX receptor beta; LXRB; LXR-b; NER; NER-I; nuclear orphan receptor LXR-beta; nuclear receptor NER; oxysterols receptor LXR-beta; RIP15; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor; UNR
- HostGoat
- IsotypeIgG
- Protein IDP55055
- Protein NameOxysterols receptor LXR-beta
- Scientific DescriptionThe liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. Candelaria NR et al., 2014, PLoS OneRead more
- Liver X receptor beta protects dopaminergic neurons in a mouse model of Parkinson disease. Dai YB et al., 2012 Aug 7, Proc Natl Acad Sci U S ARead more