MBP146-78 [188343-77-3]
SYN-1227
CAS Number188343-77-3
Product group Chemicals
Estimated Purity>95%
Molecular Weight335.4
Overview
- SupplierSYNkinase
- Product NameMBP146-78 [188343-77-3]
- Delivery Days Customer10
- CAS Number188343-77-3
- CertificationResearch Use Only
- Estimated Purity>95%
- Molecular FormulaC21H22FN3
- Molecular Weight335.4
- Scientific DescriptionChemical. CAS: 188343-77-3. Formula: C21H22FN3. MW: 335.4. MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG. MBP146-78 is a potent inhibitor of both soluble and membrane-associated isoforms of native PKG, as well as recombinant enzyme, with an IC50 of <1nm. - MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG. MBP146-78 is a potent inhibitor of both soluble and membrane-associated isoforms of native PKG, as well as recombinant enzyme, with an IC50 of <1nm.
- Storage Instruction2°C to 8°C
- UNSPSC51202000