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ProductsBack/MOTS-c (K14Q Mutant) (human)
Chemical Structure
Chemical Structure
Chemical Structure

MOTS-c (K14Q Mutant) (human)

Research Use Only
AG-CP3-0033
AdipoGen Life Sciences
Estimated Purity>95%
DownloadMSDS
Product group Chemicals
Molecular Weight2174.6 . 114.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    MOTS-c (K14Q Mutant) (human)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C100H148N28O23S2 . C2HF3O2
  • Molecular Weight
    2174.6 . 114.0
  • Scientific Description
    Chemical. Formula: C100H148N28O23S2 . C2HF3O2. MW: 2174.6 . 114.0. Synthetic. The mitochondria-derived peptide (MDP) MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity (DIO) in mice. This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research. - The mitochondria-derived peptide (MDP) MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity (DIO) in mice. This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research.
  • SMILES
    [H]N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=CC=C3)=O)[C@@H](C)CC)=O)CC4=CC=C(O)C=C4)=O)=O)CCSC)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)CCSC.O=C(O)C(F)(F)F
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • A mitochondrially encoded hormone ameliorates obesity and insulin resistance: K. Zarse & M. Ristow; Cell. Metab. 21, 355 (2015)
  • The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance: C. Lee, et al.; Cell. Metab. 21, 443 (2015)
  • The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? N. Fuku, et al.; Aging Cell 14, 921 (2015)
  • MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism: C. Lee, et al.; Free Radic. Biol. Med. 100, 182 (2016)