MDM4 Antibody, HRP conjugated
CSB-PA013627LB01HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetMDM4
Overview
- SupplierCusabio
- Product NameMDM4 Antibody, HRP conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateHRP
- Gene ID4194
- Target nameMDM4
- Target descriptionMDM4 regulator of p53
- Target synonymsBMFS6, HDMX, MDMX, MRP1, protein Mdm4, MDM4, p53 regulator, MDM4-related protein 1, Mdm4 p53 binding protein homolog, double minute 4, human homolog of; p53-binding protein, mdm2-like p53-binding protein, protein Mdmx
- HostRabbit
- IsotypeIgG
- Protein IDO15151
- Protein NameProtein Mdm4
- Scientific DescriptionInhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161



![WB analysis of MCF cells with DNA damage using GTX00677 MDMX (phospho Ser367) antibody [#15]. MCF cells were preincubated with the proteasome inhibitor MG132 (20 microM) followed by exposed to DNA damaging agents adriamycin (3 microM) or etoposide (20 microM). The cell lysates were used for immunoprecipitation with anti-MdmX antibody and then analyzed by Western blotting.Induction of S367 phosphorylation after DNA damage is associated with increased binding of 14-3-3 to MdmX and accelerated MdmX degradation.](https://www.genetex.com/upload/website/prouct_img/normal/GTX00677/GTX00677_20191104_WB_w_23053121_471.webp)




