MET (Ab-1234) Antibody

Cusabio

MET (Ab-1234) Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

MET

MET proto-oncogene, receptor tyrosine kinase

AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met, hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, SF receptor, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met

Rabbit

IgG

Hepatocyte growth factor receptor

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells. Gherardi E. et al. (2003).Proc Natl Acad Sci U S A. 100(21): 12039-12044. Shiu SH. et al. (2001) Proc Natl Acad Sci U S A. 98(19): 10763-10768. Hughes AL. et al. (2001) Genome Res. 11(5): 771-780. Onuchic LF. et al. (2002) Am J Hum Genet. 70(5): 1305-13

Human, Mouse, Rat

-20°C or -80°C

41116161