mtTFA antibody
GTX103231
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTFAM
Overview
- SupplierGeneTex
- Product NamemtTFA antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.23 mg/ml
- ConjugateUnconjugated
- Gene ID7019
- Target nameTFAM
- Target descriptiontranscription factor A, mitochondrial
- Target synonymsmitochondrial transcription factor 1; mitochondrial transcription factor A; MTDPS15; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3; transcription factor A, mitochondrial
- HostRabbit
- IsotypeIgG
- Protein IDQ00059
- Protein NameTranscription factor A, mitochondrial
- Scientific DescriptionThis gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- mtFociCounter for automated single-cell mitochondrial nucleoid quantification and reproducible foci analysis.Read more
- Fumarate induces vesicular release of mtDNA to drive innate immunity.Read more
- Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. Molina-Granada D et al., 2022 Jun 23, Commun BiolRead more
- Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria. Toda T et al., 2022 May 12, Commun BiolRead more
- SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas. Armstrong N et al., 2022 Mar 1, Cell RepRead more
- Immunofluorescence microscopy-based assessment of cytosolic DNA accumulation in mammalian cells. Sato A et al., 2021 Jun 18, STAR ProtocRead more
- Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimers disease. Roca-Agujetas V et al., 2021 Mar 8, Mol NeurodegenerRead more
- Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain. Lam HYP et al., 2021 Feb, Parasitol IntRead more
- Hypoxia potentiates the capacity of melanoma cells to evade cisplatin and doxorubicin cytotoxicity via glycolytic shift. Zhuo M et al., 2020 May, FEBS Open BioRead more
- SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. Kurundkar D et al., 2019 Jan 10, JCI InsightRead more