Bio-Connect

mtTFA antibody

GTX103231
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTFAM
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Overview

  • Supplier
    GeneTex
  • Product Name
    mtTFA antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.23 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7019
  • Target name
    TFAM
  • Target description
    transcription factor A, mitochondrial
  • Target synonyms
    mitochondrial transcription factor 1; mitochondrial transcription factor A; MTDPS15; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3; transcription factor A, mitochondrial
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ00059
  • Protein Name
    Transcription factor A, mitochondrial
  • Scientific Description
    This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • mtFociCounter for automated single-cell mitochondrial nucleoid quantification and reproducible foci analysis.
    Read more
  • Fumarate induces vesicular release of mtDNA to drive innate immunity.
    Read more
  • Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. Molina-Granada D et al., 2022 Jun 23, Commun Biol
    Read more
  • Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria. Toda T et al., 2022 May 12, Commun Biol
    Read more
  • SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas. Armstrong N et al., 2022 Mar 1, Cell Rep
    Read more
  • Immunofluorescence microscopy-based assessment of cytosolic DNA accumulation in mammalian cells. Sato A et al., 2021 Jun 18, STAR Protoc
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  • Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimers disease. Roca-Agujetas V et al., 2021 Mar 8, Mol Neurodegener
    Read more
  • Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain. Lam HYP et al., 2021 Feb, Parasitol Int
    Read more
  • Hypoxia potentiates the capacity of melanoma cells to evade cisplatin and doxorubicin cytotoxicity via glycolytic shift. Zhuo M et al., 2020 May, FEBS Open Bio
    Read more
  • SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. Kurundkar D et al., 2019 Jan 10, JCI Insight
    Read more