mtTFA antibody
GTX103231
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetTFAM
Overview
- SupplierGeneTex
- Product NamemtTFA antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.23 mg/ml
- ConjugateUnconjugated
- Gene ID7019
- Target nameTFAM
- Target descriptiontranscription factor A, mitochondrial
- Target synonymsMTDPS15, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3, transcription factor A, mitochondrial, mitochondrial transcription factor 1, mitochondrial transcription factor A, transcription factor 6, transcription factor 6-like 1, transcription factor 6-like 2 (mitochondrial transcription factor), transcription factor 6-like 3
- HostRabbit
- IsotypeIgG
- Protein IDQ00059
- Protein NameTranscription factor A, mitochondrial
- Scientific DescriptionThis gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Rey T, Tábara LC, Prudent J, et al. mtFociCounter for automated single-cell mitochondrial nucleoid quantification and reproducible foci analysis. Nucleic Acids Res. 2023,51(21):e107. doi: 10.1093/nar/gkad864Read this paper
- Zecchini V, Paupe V, Herranz-Montoya I, et al. Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature. 2023,615(7952):499-506. doi: 10.1038/s41586-023-05770-wRead this paper
- Molina-Granada D, González-Vioque E, Dibley MG, et al. Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. Commun Biol. 2022,5(1):620. doi: 10.1038/s42003-022-03568-6Read this paper
- Toda T, Ito M, Takeda JI, et al. Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria. Commun Biol. 2022,5(1):453. doi: 10.1038/s42003-022-03389-7Read this paper
- Armstrong N, Storey CM, Noll SE, et al. SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas. Cell Rep. 2022,38(9):110453. doi: 10.1016/j.celrep.2022.110453Read this paper
- Sato A, Buque A, Yamazaki T, et al. Immunofluorescence microscopy-based assessment of cytosolic DNA accumulation in mammalian cells. STAR Protoc. 2021,2(2):100488. doi: 10.1016/j.xpro.2021.100488Read this paper
- Roca-Agujetas V, Barbero-Camps E, de Dios C, et al. Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease. Mol Neurodegener. 2021,16(1):15. doi: 10.1186/s13024-021-00435-6Read this paper
- Lam HYP, Chen CC, Chen TT, et al. Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain. Parasitol Int. 2021,80:102231. doi: 10.1016/j.parint.2020.102231Read this paper
- Zhuo M, Gorgun FM, Tyler DS, et al. Hypoxia potentiates the capacity of melanoma cells to evade cisplatin and doxorubicin cytotoxicity via glycolytic shift. FEBS Open Bio. 2020,10(5):789-801. doi: 10.1002/2211-5463.12830Read this paper
- Kurundkar D, Kurundkar AR, Bone NB, et al. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019,4(1). doi: 10.1172/jci.insight.120722Read this paper
Datasheet
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