Bio-Connect

mtTFA antibody

GTX112760
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTFAM
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Overview

  • Supplier
    GeneTex
  • Product Name
    mtTFA antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.43 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7019
  • Target name
    TFAM
  • Target description
    transcription factor A, mitochondrial
  • Target synonyms
    mitochondrial transcription factor 1; mitochondrial transcription factor A; MTDPS15; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3; transcription factor A, mitochondrial
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ00059
  • Protein Name
    Transcription factor A, mitochondrial
  • Scientific Description
    This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/alphaPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING.
    Read more
  • Nrf2 Deficiency Attenuates Testosterone Efficiency in Ameliorating Mitochondrial Function of the Substantia Nigra in Aged Male Mice. Ren B et al., 2022, Oxid Med Cell Longev
    Read more
  • Testosterone ameliorates age-related brain mitochondrial dysfunction. Yan W et al., 2021 Jun 17, Aging (Albany NY)
    Read more
  • Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. Yan H et al., 2021 Aug 15, Neuropharmacology
    Read more
  • Progressive Reduction in Mitochondrial Mass Is Triggered by Alterations in Mitochondrial Biogenesis and Dynamics in Chronic Kidney Disease Induced by 5/6 Nephrectomy. Prieto-Carrasco R et al., 2021 Apr 21, Biology (Basel)
    Read more
  • Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells. Miao J et al., 2021 Jan, Physiol Rep
    Read more
  • Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits. Wang Y et al., 2020 Nov 20, Aging (Albany NY)
    Read more
  • Wnt/beta-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Miao J et al., 2019 Oct, Aging Cell
    Read more
  • The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. Qiao A et al., 2017 Mar 6, J Cell Biol
    Read more