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mtTFA antibody

GTX112760
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetTFAM
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Overview

  • Supplier
    GeneTex
  • Product Name
    mtTFA antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.43 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7019
  • Target name
    TFAM
  • Target description
    transcription factor A, mitochondrial
  • Target synonyms
    MTDPS15, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3, transcription factor A, mitochondrial, mitochondrial transcription factor 1, mitochondrial transcription factor A, transcription factor 6, transcription factor 6-like 1, transcription factor 6-like 2 (mitochondrial transcription factor), transcription factor 6-like 3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ00059
  • Protein Name
    Transcription factor A, mitochondrial
  • Scientific Description
    This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Wang L, Luo R, Onyshchenko K, et al. Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING. J Immunother Cancer. 2023,11(8). doi: 10.1136/jitc-2022-006235
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  • Ren B, Zhang T, Guo Q, et al. Nrf2 Deficiency Attenuates Testosterone Efficiency in Ameliorating Mitochondrial Function of the Substantia Nigra in Aged Male Mice. Oxid Med Cell Longev. 2022,2022:3644318. doi: 10.1155/2022/3644318
    Read this paper
  • Yan W, Zhang T, Kang Y, et al. Testosterone ameliorates age-related brain mitochondrial dysfunction. Aging (Albany NY). 2021,13(12):16229-16247. doi: 10.18632/aging.203153
    Read this paper
  • Yan H, Zhao H, Kang Y, et al. Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. Neuropharmacology. 2021,194:108627. doi: 10.1016/j.neuropharm.2021.108627
    Read this paper
  • Prieto-Carrasco R, García-Arroyo FE, Aparicio-Trejo OE, et al. Progressive Reduction in Mitochondrial Mass Is Triggered by Alterations in Mitochondrial Biogenesis and Dynamics in Chronic Kidney Disease Induced by 5/6 Nephrectomy. Biology (Basel). 2021,10(5). doi: 10.3390/biology10050349
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  • Miao J, Huang J, Luo C, et al. Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells. Physiol Rep. 2021,9(2):e14696. doi: 10.14814/phy2.14696
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  • Wang Y, Kang Y, Qi C, et al. Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits. Aging (Albany NY). 2020,12(24):25487-25504. doi: 10.18632/aging.104155
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  • Miao J, Liu J, Niu J, et al. Wnt/β-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Aging Cell. 2019,18(5):e13004. doi: 10.1111/acel.13004
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  • Qiao A, Jin X, Pang J, et al. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol. 2017,216(3):723-741. doi: 10.1083/jcb.201607091
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