mtTFA antibody
GTX112760
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTFAM
Overview
- SupplierGeneTex
- Product NamemtTFA antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.43 mg/ml
- ConjugateUnconjugated
- Gene ID7019
- Target nameTFAM
- Target descriptiontranscription factor A, mitochondrial
- Target synonymsmitochondrial transcription factor 1; mitochondrial transcription factor A; MTDPS15; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3; transcription factor A, mitochondrial
- HostRabbit
- IsotypeIgG
- Protein IDQ00059
- Protein NameTranscription factor A, mitochondrial
- Scientific DescriptionThis gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/alphaPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING.Read more
- Nrf2 Deficiency Attenuates Testosterone Efficiency in Ameliorating Mitochondrial Function of the Substantia Nigra in Aged Male Mice. Ren B et al., 2022, Oxid Med Cell LongevRead more
- Testosterone ameliorates age-related brain mitochondrial dysfunction. Yan W et al., 2021 Jun 17, Aging (Albany NY)Read more
- Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. Yan H et al., 2021 Aug 15, NeuropharmacologyRead more
- Progressive Reduction in Mitochondrial Mass Is Triggered by Alterations in Mitochondrial Biogenesis and Dynamics in Chronic Kidney Disease Induced by 5/6 Nephrectomy. Prieto-Carrasco R et al., 2021 Apr 21, Biology (Basel)Read more
- Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells. Miao J et al., 2021 Jan, Physiol RepRead more
- Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits. Wang Y et al., 2020 Nov 20, Aging (Albany NY)Read more
- Wnt/beta-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Miao J et al., 2019 Oct, Aging CellRead more
- The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. Qiao A et al., 2017 Mar 6, J Cell BiolRead more