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ProductsBack/Myeloperoxidase antibody [2C7]

Myeloperoxidase antibody [2C7]

GTX75315
GeneTex
ApplicationsFlow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetMPO
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Overview

  • Supplier
    GeneTex
  • Product Name
    Myeloperoxidase antibody [2C7]
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody recognizes recombinant MPO in Western blots and weakly in ELISA.Mouse anti Human Myeloperoxidase antibody, clone 2C7 may be of value in the study of myeloid cells and myeloid leukaemias by flow cytometry following cell permeablisation.
  • Application Supplier Note
    IHC-P: 1/500-1/1,000. IHC-Fr: 1/1,000-1/5,000. FACS: 1/50-1/100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2C7
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4353
  • Target name
    MPO
  • Target description
    myeloperoxidase
  • Target synonyms
    myeloperoxidase
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP05164
  • Protein Name
    Myeloperoxidase
  • Scientific Description
    Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis.
    Read more
  • Decreased Tissue Omega-6/Omega-3 Fatty Acid Ratio Prevents Chemotherapy-Induced Gastrointestinal Toxicity Associated with Alterations of Gut Microbiome. Kaliannan K et al., 2022 May 10, Int J Mol Sci
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  • An Autopsy Case of Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody (MPO-ANCA)-associated Vasculitis Accompanied by Cryoglobulinemic Vasculitis Affecting the Kidneys, Skin, and Gastrointestinal Tract. Hasegawa J et al., 2018 Sep 15, Intern Med
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  • Vanishing Immunoglobulins: The Formation of Pauci-Immune Lesions in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Futamata E et al., 2018, Nephron
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  • Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils. Rocha JD et al., 2015 Jan 26, Sci Rep
    Read more
  • LRRK2 is involved in the IFN-gamma response and host response to pathogens. Gardet A et al., 2010 Nov 1, J Immunol
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  • Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF). Brzezinska AA et al., 2009 Jul, Immunology
    Read more