NBS1 antibody [1C3]
GTX70222
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetNBN
Overview
- SupplierGeneTex
- Product NameNBS1 antibody [1C3] - KO/KD Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1C3
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID4683
- Target nameNBN
- Target descriptionnibrin
- Target synonymsATV; AT-V1; AT-V2; cell cycle regulatory protein p95; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); P95; p95 protein of the MRE11/RAD50 complex
- HostMouse
- IsotypeIgG1
- Protein IDO60934
- Protein NameNibrin
- Scientific DescriptionMutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations. Tomioka K et al., 2021 Oct 4, Sci RepRead more
- Productive herpesvirus lytic replication in primary effusion lymphoma cells requires S-phase entry. Hollingworth R et al., 2020 Aug, J Gen VirolRead more
- FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses. Qi F et al., 2020 May 22, J Radiat ResRead more
- Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Raghunandan M et al., 2020 May 8, Hum Mol GenetRead more
- Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Ly P et al., 2019 Apr, Nat GenetRead more
- Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposis Sarcoma-Associated Herpesvirus. Hollingworth R et al., 2017 Nov 15, J VirolRead more
- The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Petroni M et al., 2016 Feb, Cell Death DifferRead more
- The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. Harten SK et al., 2015 Mar 26, BMC BiolRead more
- The telomere deprotection response is functionally distinct from the genomic DNA damage response. Cesare AJ et al., 2013 Jul 25, Mol CellRead more
- CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Anderson VE et al., 2011 Jan 15, Cancer ResRead more
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