NBS1 antibody [1C3]
GTX70222
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetNBN
Overview
- SupplierGeneTex
- Product NameNBS1 antibody [1C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1C3
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID4683
- Target nameNBN
- Target descriptionnibrin
- Target synonymsAT-V1, AT-V2, ATV, NBS, NBS1, P95, hNbs1, nibrin, Nijmegen breakage syndrome 1 (nibrin), cell cycle regulatory protein p95, p95 protein of the MRE11/RAD50 complex
- HostMouse
- IsotypeIgG1
- Protein IDO60934
- Protein NameNibrin
- Scientific DescriptionMutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Tomioka K, Miyamoto T, Akutsu SN, et al. NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations. Sci Rep. 2021,11(1):19661. doi: 10.1038/s41598-021-98673-7Read this paper
- Hollingworth R, Stewart GS, Grand RJ. Productive herpesvirus lytic replication in primary effusion lymphoma cells requires S-phase entry. J Gen Virol. 2020,101(8):873-883. doi: 10.1099/jgv.0.001444Read this paper
- Qi F, Meng Q, Hayashi I, et al. FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses. J Radiat Res. 2020,61(3):368-375. doi: 10.1093/jrr/rraa011Read this paper
- Raghunandan M, Yeo JE, Walter R, et al. Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Hum Mol Genet. 2020,29(7):1083-1095. doi: 10.1093/hmg/ddz250Read this paper
- Ly P, Brunner SF, Shoshani O, et al. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019,51(4):705-715. doi: 10.1038/s41588-019-0360-8Read this paper
- Hollingworth R, Horniblow RD, Forrest C, et al. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2017,91(22). doi: 10.1128/JVI.00930-17Read this paper
- Petroni M, Sardina F, Heil C, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016,23(2):197-206. doi: 10.1038/cdd.2015.81Read this paper
- Harten SK, Oey H, Bourke LM, et al. The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. BMC Biol. 2015,13:21. doi: 10.1186/s12915-015-0128-2Read this paper
- Cesare AJ, Hayashi MT, Crabbe L, et al. The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell. 2013,51(2):141-55. doi: 10.1016/j.molcel.2013.06.006Read this paper
- Anderson VE, Walton MI, Eve PD, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011,71(2):463-72. doi: 10.1158/0008-5472.CAN-10-1252Read this paper
Datasheet
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