NBS1 antibody [1D7]
GTX70224
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetNBN
Overview
- SupplierGeneTex
- Product NameNBS1 antibody [1D7]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1D7
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID4683
- Target nameNBN
- Target descriptionnibrin
- Target synonymsAT-V1, AT-V2, ATV, NBS, NBS1, P95, hNbs1, nibrin, Nijmegen breakage syndrome 1 (nibrin), cell cycle regulatory protein p95, p95 protein of the MRE11/RAD50 complex
- HostMouse
- IsotypeIgG1
- Protein IDO60934
- Protein NameNibrin
- Scientific DescriptionMutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- McGrail DJ, Li Y, Smith RS, et al. Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins. Cell Rep Med. 2023,4(11):101255. doi: 10.1016/j.xcrm.2023.101255Read this paper
- Grange LJ, Reynolds JJ, Ullah F, et al. Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy. Nat Commun. 2022,13(1):6664. doi: 10.1038/s41467-022-34349-8Read this paper
- Xiao H, Li F, Mladenov E, et al. Increased Resection at DSBs in G(2)-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ. Cells. 2022,11(13). doi: 10.3390/cells11132099Read this paper
- Tsaridou S, Velimezi G, Willenbrock F, et al. 53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling. EMBO Rep. 2022,23(8):e54483. doi: 10.15252/embr.202154483Read this paper
- Wang F, Jin S, Mayca Pozo F, et al. Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR. Acta Pharm Sin B. 2022,12(3):1339-1350. doi: 10.1016/j.apsb.2021.08.025Read this paper
- Boddin J, Ip WH, Wilkens B, et al. A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. mBio. 2022,13(2):e0014422. doi: 10.1128/mbio.00144-22Read this paper
- Abu-Libdeh B, Jhujh SS, Dhar S, et al. RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. J Clin Invest. 2022,132(5). doi: 10.1172/JCI147301Read this paper
- Ko JMY, Lam SY, Ning L, et al. RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma. Cancers (Basel). 2021,13(18). doi: 10.3390/cancers13184715Read this paper
- Du Y, Sun H, Lux F, et al. Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer. ACS Appl Mater Interfaces. 2020,12(51):56874-56885. doi: 10.1021/acsami.0c16548Read this paper
- Zhou ZW, Kirtay M, Schneble N, et al. NBS1 interacts with Notch signaling in neuronal homeostasis. Nucleic Acids Res. 2020,48(19):10924-10939. doi: 10.1093/nar/gkaa716Read this paper
Datasheet
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