NBS1 antibody [1D7]
GTX70224
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetNBN
Overview
- SupplierGeneTex
- Product NameNBS1 antibody [1D7] - KO/KD Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1D7
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID4683
- Target nameNBN
- Target descriptionnibrin
- Target synonymsATV; AT-V1; AT-V2; cell cycle regulatory protein p95; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); P95; p95 protein of the MRE11/RAD50 complex
- HostMouse
- IsotypeIgG1
- Protein IDO60934
- Protein NameNibrin
- Scientific DescriptionMutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins.Read more
- Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.Read more
- Increased Resection at DSBs in G(2)-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ. Xiao H et al., 2022 Jul 2, CellsRead more
- 53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling. Tsaridou S et al., 2022 Aug 3, EMBO RepRead more
- Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR. Wang F et al., 2022 Mar, Acta Pharm Sin BRead more
- A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. Boddin J et al., 2022 Apr 26, mBioRead more
- RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. Abu-Libdeh B et al., 2022 Mar 1, J Clin InvestRead more
- RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma. Ko JMY et al., 2021 Sep 21, Cancers (Basel)Read more
- Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer. Du Y et al., 2020 Dec 23, ACS Appl Mater InterfacesRead more
- NBS1 interacts with Notch signaling in neuronal homeostasis. Zhou ZW et al., 2020 Nov 4, Nucleic Acids ResRead more