ProductsBack/NBS1 antibody [1D7]

NBS1 antibody [1D7]

Name: NBS1 antibody [1D7]
SKU: GTX70224_G10
Availability: BackOrder

GTX70224

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

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Product group Antibodies

TargetNBN

Overview

Supplier
GeneTex
Product Name
NBS1 antibody [1D7] - KO/KD Validated
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
1D7
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID4683
Target name
NBN
Target description
nibrin
Target synonyms
ATV; AT-V1; AT-V2; cell cycle regulatory protein p95; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); P95; p95 protein of the MRE11/RAD50 complex
Host
Mouse
Isotype
IgG1
Protein IDO60934
Protein Name
Nibrin
Scientific Description
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins.
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Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.
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Increased Resection at DSBs in G(2)-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ. Xiao H et al., 2022 Jul 2, Cells
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53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling. Tsaridou S et al., 2022 Aug 3, EMBO Rep
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Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR. Wang F et al., 2022 Mar, Acta Pharm Sin B
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A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. Boddin J et al., 2022 Apr 26, mBio
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RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. Abu-Libdeh B et al., 2022 Mar 1, J Clin Invest
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RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma. Ko JMY et al., 2021 Sep 21, Cancers (Basel)
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Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer. Du Y et al., 2020 Dec 23, ACS Appl Mater Interfaces
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NBS1 interacts with Notch signaling in neuronal homeostasis. Zhou ZW et al., 2020 Nov 4, Nucleic Acids Res
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NBS1 antibody [1D7]

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Overview

References

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